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Published Articles >> Table of Contents >> Abstract
28th Hawaii International Conference on System Sciences (HICSS'95)
p. 325
Practical use of a fully automatic homology-based protein modelling protocol
E. Platt, Proteus Molecular Design Ltd., Macclesfield, UK
B. Robson, Proteus Molecular Design Ltd., Macclesfield, UK
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DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/HICSS.1995.375323
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| Abstract |
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Like secondary structure prediction, we believe that tertiary structure prediction should also be automatic, and hence reproducible. A fully automatic protocol called HOM FOLD, for modelling proteins by homology using a fragment-based approach, is described. This paper describes the performance of the basic algorithm. Written in the GLOBAL language, it is a simple matter to add further knowledge and expertise as new rules in the protocol. The protocol was intended to be, and is normally used as, a first step only, with more elaborate algorithms for energy refinement to be applied subsequently in the context of a higher-level protocol. However, structures in agreement within 1.80 /spl Aring/ X-ray crystallographic data can be achieved that are at least as good as that obtained by interactive modelling and refinement.
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 Additional Information
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Index Terms- proteins; biology computing; molecular configurations; molecular biophysics; fully automatic homology-based protein modelling protocol; tertiary structure prediction; HOM FOLD; fragment-based approach; algorithm performance; GLOBAL language; rule based system; energy refinement; X-ray crystallographic data; interactive modelling; reproducibilty; 1.80 angstrom
Citation:
E. Platt, B. Robson,
"Practical use of a fully automatic homology-based protein modelling protocol,"
hicss,
p. 325,
28th Hawaii International Conference on System Sciences (HICSS'95),
1995
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